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Journal of Biomedical Optics

Antibody-labeled fluorescence imaging of dendritic cell populations in vivo
Author(s): Ryan J. Cummings; Soumya Mitra; Edith M. Lord; Thomas H. Foster
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Paper Abstract

We report an optical molecular imaging technique that exploits local administration of fluorophore-conjugated antibodies and confocal fluorescence microscopy to achieve high-contrast imaging of host cell populations in normal and tumor tissue in living mice. The method achieves micron-scale spatial resolution to depths greater than 100 μm. We illustrate the capabilities of this approach by imaging two dendritic cell populations in the skin and normal and tumor vasculature in vivo.

Paper Details

Date Published: 1 July 2008
PDF: 5 pages
J. Biomed. Opt. 13(4) 044041 doi: 10.1117/1.2966122
Published in: Journal of Biomedical Optics Volume 13, Issue 4
Show Author Affiliations
Ryan J. Cummings, Univ. of Rochester Medical Ctr. (United States)
Soumya Mitra, Univ. of Rochester Medical Ctr. (United States)
Edith M. Lord, Univ. of Rochester Medical Ctr. (United States)
Thomas H. Foster, Univ. of Rochester Medical Ctr. (United States)

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