Share Email Print

Journal of Biomedical Optics

Tomographic x-ray–guided three-dimensional diffuse optical tomography of osteoarthritis in the finger joints
Author(s): Zhen Yuan; Qizhi Zhang; Eric S. Sobel; Huabei Jiang
Format Member Price Non-Member Price
PDF $20.00 $25.00
cover GOOD NEWS! Your organization subscribes to the SPIE Digital Library. You may be able to download this paper for free. Check Access

Paper Abstract

We describe a multimodality imaging approach that combines x-ray tomosynthesis with near-infrared diffuse optical tomography (DOT) for high-resolution imaging of osteoarthritis in the finger joints. In this approach, we take advantage of high resolution x-ray imaging particularly of the bones and incorporate the fine structural maps obtained from x ray as a priori information into DOT reconstructions. To realize this multi-modality approach, we constructed a hybrid imaging platform that integrated a C-arm–based x-ray tomosynthetic system with a multichannel optic-fiber–based DOT system. We also implemented improved hybrid regularization-based reconstruction algorithms that have shown to be especially effective for high-resolution modality-guided DOT. Initial evaluation of our x-ray–guided DOT reconstruction approach in the finger joints shows that spatial resolution of DOT can be enhanced dramatically when the three-dimensional geometry of bones is known a priori. In particular, the improved quantitative capability of imaging absorption and scattering coefficients of the joint tissues allows for more accurate diagnosis of osteoarthritis over x-ray radiography or DOT alone.

Paper Details

Date Published: 1 July 2008
PDF: 10 pages
J. Biomed. Opt. 13(4) 044006 doi: 10.1117/1.2965547
Published in: Journal of Biomedical Optics Volume 13, Issue 4
Show Author Affiliations
Zhen Yuan, Univ. of Florida (United States)
Qizhi Zhang, Univ. of Florida (United States)
Eric S. Sobel, Univ. of Florida (United States)
Huabei Jiang, Univ. of Florida (United States)

© SPIE. Terms of Use
Back to Top