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Journal of Biomedical Optics

Changes in optical properties of tissue during acute wound healing in an animal model
Author(s): Elisabeth S. Papazoglou; Michael S. Weingarten; Leonid Zubkov; Michael T. Neidrauer; Linda S. Zhu; Som D. Tyagi; Kambiz Pourrezaei
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Paper Abstract

Changes of optical properties of wound tissue in hairless rats were quantified by diffuse photon density wave methodology at near-infrared frequencies. The diffusion equation for semi-infinite media was used to calculate the absorption and scattering coefficients based on measurements of phase and amplitude with a frequency domain device. There was an increase in the absorption and scattering coefficients and a decrease in blood saturation of the wounds compared with the nonwounded sites. The changes correlated with the healing stage of the wound. The data obtained were supported by immunohistochemical analysis of wound tissue. These results verified now by two independent animal studies could suggest a noninvasive method to detect the progress of wound healing.

Paper Details

Date Published: 1 July 2008
PDF: 11 pages
J. Biomed. Opt. 13(4) 044005 doi: 10.1117/1.2960952
Published in: Journal of Biomedical Optics Volume 13, Issue 4
Show Author Affiliations
Elisabeth S. Papazoglou, Drexel Univ. (United States)
Michael S. Weingarten, Drexel Univ. College of Medicine (United States)
Leonid Zubkov, Drexel Univ. (United States)
Michael T. Neidrauer, Drexel Univ. (United States)
Linda S. Zhu, Drexel Univ. (United States)
Som D. Tyagi, Drexel Univ. (United States)
Kambiz Pourrezaei, Drexel Univ. (United States)


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