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Journal of Biomedical Optics

Delineation of an oral cancer lesion with swept-source optical coherence tomography
Author(s): Meng-Tsan Tsai; Hsiang-Chieh Lee; Chih-Wei Lu; Yih-Ming Wang; Cheng-Kuan Lee; Chi-Chung Yang; Chun-Ping Chiang
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Paper Abstract

We demonstrate the ex vivo imaging of an oral cancerous sample with a swept-source optical coherence tomography (SS-OCT) system. With the axial resolution of 8 µm in free space and system sensitivity of 108 dB, we can well distinguish the normal and abnormal tissue portions in a sample. In particular, we analyze the lateral variation of A-scan profiles to show two parameters of SS-OCT signal for delineating an oral cancer lesion. One of the parameters is the decay constant in the exponential fitting of the SS-OCT signal intensity along depth. This decay constant decreases as the A-scan point moves laterally across the margin of a lesion. The other parameter is the standard deviation of the SS-OCT signal intensity fluctuation in an A-scan. This parameter increases significantly when the A-scan point is moved across the transition region between the normal and abnormal portions. Such parameters are useful for determining the margins of oral cancer.

Paper Details

Date Published: 1 July 2008
PDF: 6 pages
J. Biomed. Opt. 13(4) 044012 doi: 10.1117/1.2960632
Published in: Journal of Biomedical Optics Volume 13, Issue 4
Show Author Affiliations
Meng-Tsan Tsai, National Taiwan Univ. (Taiwan)
Hsiang-Chieh Lee, National Taiwan Univ. (Taiwan)
Chih-Wei Lu, National Taiwan Univ. (Taiwan)
Yih-Ming Wang, National Taiwan Univ. (Taiwan)
Cheng-Kuan Lee, National Taiwan Univ. (Taiwan)
Chi-Chung Yang, National Taiwan Univ. (Taiwan)
Chun-Ping Chiang, National Taiwan Univ. (Taiwan)

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