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Journal of Biomedical Optics • Open Access

Fingerprint and high-wavenumber Raman spectroscopy in a human-swine coronary xenograft in vivo
Author(s): Alexandra H. Chau; Jason T. Motz; Joseph A. Gardecki; Sergio Waxman; Brett E. Bouma; Guillermo J. Tearney

Paper Abstract

Intracoronary Raman spectroscopy could open new avenues for the study and management of coronary artery disease due to its potential to measure the chemical and molecular composition of coronary atherosclerotic lesions. We have fabricated and tested a 1.5-mm-diameter (4.5 Fr) Raman catheter capable of collecting Raman spectra in both the fingerprint (400–1800 cm-1) and high-wavenumber (2400–3800 cm-1) regions. Spectra were acquired in vivo, using a human-swine xenograft model, in which diseased human coronary arteries are grafted onto a living swine heart, replicating the disease and dynamic environment of the human circulatory system, including pulsatile flow and motion. Results show that distinct spectral differences, corresponding to the morphology and chemical composition of the artery wall, can be identified by intracoronary Raman spectroscopy in vivo.

Paper Details

Date Published: 1 July 2008
PDF: 3 pages
J. Biomed. Opt. 13(4) 040501 doi: 10.1117/1.2960015
Published in: Journal of Biomedical Optics Volume 13, Issue 4
Show Author Affiliations
Alexandra H. Chau, Massachusetts General Hospital (United States)
Jason T. Motz, Massachusetts General Hospital (United States)
Joseph A. Gardecki, Massachusetts Institute of Technology (United States)
Sergio Waxman, Lahey Clinic Medical Ctr. (United States)
Brett E. Bouma, Massachusetts General Hospital (United States)
Guillermo J. Tearney, Massachusetts General Hospital (United States)


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