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Journal of Biomedical Optics

Temperature dependence of near-infrared spectra of whole blood
Author(s): Paul Martinsen; Jean-Luc Charlier; Tim Wilcox; Guy Warman; Andrew McGlone; Rainer Kunnemeyer
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Paper Abstract

The temperature dependence (30 to 40°C) of near-infrared spectra (500 to 1100 nm) of whole human blood, including red blood cells with intact physiological function, is investigated. Previous studies have focused on hemoglobin solutions, but the operation of red blood cells is critically dependent on intact cell membranes to perform normal oxygen transport and other physiological functions. Thus measurements of whole blood are more directly related to changes that occur in vivo. In addition to the response of hemoglobin to temperature in the spectra, a temperature response from water in the plasma is also detected. The temperature response of the water absorption at 960 nm is approximately ten times smaller than the temperature response of the oxyhemoglobin component in the blood at 610 nm. However, it is the most significant temperature effect between 800 and 1000 nm. This work will aid the precision and understanding of full spectrum near-infrared measurements on blood.

Paper Details

Date Published: 1 May 2008
PDF: 7 pages
J. Biomed. Opt. 13(3) 034016 doi: 10.1117/1.2943191
Published in: Journal of Biomedical Optics Volume 13, Issue 3
Show Author Affiliations
Paul Martinsen, Hort Research (New Zealand)
Jean-Luc Charlier, Auckland City Hospital (New Zealand)
Tim Wilcox, The Univ. of Auckland (New Zealand)
Guy Warman, The Univ. of Auckland (New Zealand)
Andrew McGlone, Hort Research (New Zealand)
Rainer Kunnemeyer, The Univ. of Waikato (New Zealand)

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