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Journal of Biomedical Optics

Photoacoustic imaging and temperature measurement for photothermal cancer therapy
Author(s): Jignesh Shah; Suhyun Park; Salavat R. Aglyamov; Timothy Larson; Li Ma; Konstantin V. Sokolov; Keith P. Johnston; Thomas E. Milner; Stanislav Y. Emelianov
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Paper Abstract

Photothermal therapy is a noninvasive, targeted, laser-based technique for cancer treatment. During photothermal therapy, light energy is converted to heat by tumor-specific photoabsorbers. The corresponding temperature rise causes localized cancer destruction. For effective treatment, however, the presence of photoabsorbers in the tumor must be ascertained before therapy and thermal imaging must be performed during therapy. This study investigates the feasibility of guiding photothermal therapy by using photoacoustic imaging to detect photoabsorbers and to monitor temperature elevation. Photothermal therapy is carried out by utilizing a continuous wave laser and metal nanocomposites broadly absorbing in the near-infrared optical range. A linear array-based ultrasound imaging system is interfaced with a nanosecond pulsed laser to image tissue-mimicking phantoms and ex-vivo animal tissue before and during photothermal therapy. Before commencing therapy, photoacoustic imaging identifies the presence and spatial location of nanoparticles. Thermal maps are computed by monitoring temperature-induced changes in the photoacoustic signal during the therapeutic procedure and are compared with temperature estimates obtained from ultrasound imaging. The results of our study suggest that photoacoustic imaging, augmented by ultrasound imaging, is a viable candidate to guide photoabsorber-enhanced photothermal therapy.

Paper Details

Date Published: 1 May 2008
PDF: 9 pages
J. Biomed. Opt. 13(3) 034024 doi: 10.1117/1.2940362
Published in: Journal of Biomedical Optics Volume 13, Issue 3
Show Author Affiliations
Jignesh Shah, The Univ. of Texas at Austin (United States)
Suhyun Park, The Univ. of Texas at Austin (United States)
Salavat R. Aglyamov, The Univ. of Texas at Austin (United States)
Timothy Larson, The Univ. of Texas at Austin (United States)
Li Ma, The Univ. of Texas at Austin (United States)
Konstantin V. Sokolov, The Univ. of Texas M.D. Anderson Cancer Ctr. (United States)
Keith P. Johnston, The Univ. of Texas at Austin (United States)
Thomas E. Milner, The Univ. of Texas at Austin (United States)
Stanislav Y. Emelianov, The Univ. of Texas at Austin (United States)


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