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Journal of Biomedical Optics • Open Access

Monitoring Pc 4 photodynamic therapy in clinical trials of cutaneous T-cell lymphoma using noninvasive spectroscopy
Author(s): Tammy K. Lee; Elma D. Baron; Thomas H. Foster

Paper Abstract

Silicon phthalocyanine Pc 4 photodynamic therapy (Pc 4-PDT) has emerged as a potentially effective treatment for cutaneous T-cell lymphoma (CTCL). Noninvasive reflectance and fluorescence spectroscopy before, during, and after PDT may provide useful dose metrics and enable therapy to be tailored to individual lesions. We present the design and implementation of a portable bedside spectroscopy system for initial clinical trials of Pc 4-PDT of CTCL. Reflectance and fluorescence spectra were obtained from an early stage CTCL patient throughout the course of the PDT treatment. Preliminary patient data show a significant effect of Pc 4 on the tissue absorption, modest Pc 4 photobleaching, and heterogeneity of Pc 4 within and between the lesions.

Paper Details

Date Published: 1 May 2008
PDF: 3 pages
J. Biomed. Opt. 13(3) 030507 doi: 10.1117/1.2939068
Published in: Journal of Biomedical Optics Volume 13, Issue 3
Show Author Affiliations
Tammy K. Lee, Univ. of Rochester (United States)
Elma D. Baron, Case Western Reserve Univ. (United States)
Thomas H. Foster, Univ. of Rochester (United States)

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