Share Email Print
cover

Journal of Biomedical Optics • Open Access

Quantification of cardiac fiber orientation using optical coherence tomography
Author(s): Christine P. Fleming; Crystal M. Ripplinger; Bryan Webb; Igor R. Efimov; Andrew M. Rollins

Paper Abstract

Heterogeneity in cardiac tissue microstructure is a potential mechanism for the generation and maintenance of arrhythmias. Abnormal changes in fiber orientation increase the likelihood of arrhythmia. We present optical coherence tomography (OCT) as a method to image myofibers in excised intact heart preparations. Three-dimensional (3-D) image sets were gathered from the rabbit right ventricular free wall (RVFW) using a microscope-integrated OCT system. An automated algorithm for fiber orientation quantification in the plane parallel to the wall surface was developed. The algorithm was validated by comparison with manual measurements. Quantifying fiber orientation in the plane parallel to the wall surface from OCT images can be used to help understand the conduction system of the specific sample being imaged.

Paper Details

Date Published: 1 May 2008
PDF: 3 pages
J. Biomed. Opt. 13(3) 030505 doi: 10.1117/1.2937470
Published in: Journal of Biomedical Optics Volume 13, Issue 3
Show Author Affiliations
Christine P. Fleming, Case Western Reserve Univ. (United States)
Crystal M. Ripplinger, Washington Univ. in St. Louis (United States)
Bryan Webb, Case Western Reserve Univ. (United States)
Igor R. Efimov, Washington Univ. in St. Louis (United States)
Andrew M. Rollins, Case Western Reserve Univ. (United States)


© SPIE. Terms of Use
Back to Top