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Journal of Biomedical Optics • Open Access

Mid-infrared reflectivity of experimental atheromas
Author(s): Hoi-Ying N. Holman; Kathy A. Bjornstad; Michael C. Martin; Wayne R. McKinney; Eleanor A. Blakely; Francis G. Blankenberg

Paper Abstract

We report that the pathologic components present within the atheromatous plaques of ApoE knock-out mice can reflect significant amounts of mid-infrared (mid-IR) light. Furthermore, the reflected light spectra contained the unique signatures of a variety of biologic features including those found in unstable or "vulnerable" plaque. This discovery may represent a unique opportunity to develop a new intravascular diagnostic modality that can detect and characterize sites of atherosclerosis.

Paper Details

Date Published: 1 May 2008
PDF: 3 pages
J. Biomed. Opt. 13(3) 030503 doi: 10.1117/1.2937469
Published in: Journal of Biomedical Optics Volume 13, Issue 3
Show Author Affiliations
Hoi-Ying N. Holman, Lawrence Berkeley National Lab. (United States)
Kathy A. Bjornstad, Lawrence Berkeley National Lab. (United States)
Michael C. Martin, Lawrence Berkeley National Lab. (United States)
Wayne R. McKinney, Lawrence Berkeley National Lab. (United States)
Eleanor A. Blakely, Lawrence Berkeley National Lab. (United States)
Francis G. Blankenberg, Lucile Packard Children's Hospital (United States)


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