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Journal of Biomedical Optics

Is exhaled carbon monoxide level associated with blood glucose level? A comparison of two breath analyzing methods
Author(s): Thomas Fritsch; Maarten M.J.W. van Herpen; Golo von Basum; Peter Hering; Manfred Mürtz
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Paper Abstract

The level of exhaled carbon monoxide (eCO) is considered a marker of oxidative stress in diabetes. Previous findings indicated that eCO levels correlated with blood glucose level. The aim of this work was to apply and compare two independent analyzing methods for eCO after oral glucose administration. Glycemia, eCO, and exhaled hydrogen were measured before and after oral administration of glucose. Six healthy nonsmoking volunteers participated. For eCO analysis, we used two methods: a commercially available electrochemical sensor, and a high-precision laser spectrometer developed in our laboratory. The precision of laser-spectroscopic eCO measurements was two orders of magnitude better than the precision of the electrochemical eCO measurement. eCO levels measured by laser spectrometry after glucose administration showed a decrease of 4.1%±1.5% compared to the baseline (p<0.05). Changes in the eCO measured by the electrochemical sensor were not significant (p=0.08). Exhaled hydrogen levels increased by 40% within the first 10 min after glucose administration (p<0.05). The previous finding that the glycemia increase after glucose administration was associated with a significant increase in eCO concentrations was not confirmed. We propose that previous eCO measurements with electrochemical sensors may have been affected by cross sensitivity to hydrogen.

Paper Details

Date Published: 1 May 2008
PDF: 5 pages
J. Biomed. Opt. 13(3) 034012 doi: 10.1117/1.2937215
Published in: Journal of Biomedical Optics Volume 13, Issue 3
Show Author Affiliations
Thomas Fritsch, Heinrich-Heine-Univ. Düsseldorf (Germany)
Maarten M.J.W. van Herpen, Philips Research (Netherlands)
Golo von Basum, Philips Research (Netherlands)
Peter Hering, Heinrich-Heine-Univ. Düsseldorf (Germany)
Manfred Mürtz, Heinrich-Heine-Univ. Düsseldorf (Germany)

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