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Journal of Biomedical Optics

Phase-modulation laser interference microscopy: an advance in cell imaging and dynamics study
Author(s): A. R. Brazhe; N. A. Brazhe; G. V. Maksimov; P. S. Ignatyev; A. B. Rubin; E. Mosekilde; Olga V. Sosnovtseva
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Paper Abstract

We describe how phase-modulation laser interference microscopy and wavelet analysis can be applied to noninvasive nonstained visualization and study of the structural and dynamical properties of living cells. We show how phase images of erythrocytes can reveal the difference between various erythrocyte forms and stages of hemolysis and how phase images of neurons reveal their complex intracellular structure. Temporal variations of the refractive index are analyzed to detect cellular rhythmic activity on different time scales as well as to uncover interactions between the cellular processes.

Paper Details

Date Published: 1 May 2008
PDF: 9 pages
J. Biomed. Opt. 13(3) 034004 doi: 10.1117/1.2937213
Published in: Journal of Biomedical Optics Volume 13, Issue 3
Show Author Affiliations
A. R. Brazhe, Lomonosov Moscow State Univ. (Russian Federation)
N. A. Brazhe, Lomonosov Moscow State Univ. (Russian Federation)
G. V. Maksimov, Lomonosov Moscow State Univ. (Russian Federation)
P. S. Ignatyev, AMPHORA Labs Co., Ltd. (Russian Federation)
A. B. Rubin, Danmarks Tekniske Univ. (Denmark)
E. Mosekilde, Danmarks Tekniske Univ. (Denmark)
Olga V. Sosnovtseva, Danmarks Tekniske Univ. (Denmark)

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