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Journal of Biomedical Optics

Pulsed diode laser-based monitor for singlet molecular oxygen
Author(s): Seonkyung Lee; Leyun Zhu; Ahmed M. Minhaj; Michael F. Hinds; Danthu H. Vu; David I. Rosen; Steven J. Davis; Tayyaba Hasan
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Paper Abstract

Photodynamic therapy (PDT) is a promising cancer treatment. PDT uses the affinity of photosensitizers to be selectively retained in malignant tumors. When tumors, pretreated with the photosensitizer, are irradiated with visible light, a photochemical reaction occurs and tumor cells are destroyed. Oxygen molecules in the metastable singlet delta state O2(1Δ) are believed to be the species that destroys cancerous cells during PDT. Monitoring singlet oxygen produced by PDT may lead to more precise and effective PDT treatments. Our approach uses a pulsed diode laser-based monitor with optical fibers and a fast data acquisition system to monitor singlet oxygen during PDT. We present results of in vitro singlet oxygen detection in solutions and in a rat prostate cancer cell line as well as PDT mechanism modeling.

Paper Details

Date Published: 1 May 2008
PDF: 8 pages
J. Biomed. Opt. 13(3) 034010 doi: 10.1117/1.2927465
Published in: Journal of Biomedical Optics Volume 13, Issue 3
Show Author Affiliations
Seonkyung Lee, Physical Sciences Inc. (United States)
Leyun Zhu, Physical Sciences Inc. (United States)
Ahmed M. Minhaj, Physical Sciences Inc. (United States)
Michael F. Hinds, Physical Sciences Inc. (United States)
Danthu H. Vu, Physical Sciences Inc. (United States)
David I. Rosen, Physical Sciences Inc. (United States)
Steven J. Davis, Physical Sciences Inc. (United States)
Tayyaba Hasan, Massachusetts General Hospital (United States)

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