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Journal of Biomedical Optics • Open Access

Sentinel lymph node detection ex vivo using ultrasound-modulated optical tomography

Paper Abstract

We apply ultrasound-modulated optical tomography (UOT) to image ex-vivo methylene-blue-dyed sentinel lymph nodes embedded in 3.2-cm-thick chicken breast tissues. The UOT system is implemented for the first time using ring-shaped light illumination, intense acoustic bursts, and charge-coupled device (CCD) camera-based speckle contrast detection. Since the system is noninvasive, nonionizing, portable, relatively cost effective, and easy to combine with photoacoustic imaging and single element ultrasonic pulse-echo imaging, UOT can potentially be a good imaging modality for the detection of sentinel lymph nodes in breast cancer staging in vivo.

Paper Details

Date Published: 1 March 2008
PDF: 3 pages
J. Biomed. Opt. 13(2) 020507 doi: 10.1117/1.2907791
Published in: Journal of Biomedical Optics Volume 13, Issue 2
Show Author Affiliations
Chulhong Kim, Washington Univ. in St. Louis (United States)
Kwanghyun Song, Washington Univ. in St. Louis (United States)
Lihong V. Wang, Washington Univ. in St. Louis (United States)


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