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Journal of Biomedical Optics

Curved array photoacoustic tomographic system for small animal imaging
Author(s): John Kenneth Gamelin; Andres Aquirre; Anastasios Maurudis; Fei Huang; Diego Castillo; Lihong V. Wang; Quing Zhu
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Paper Abstract

We present systematic characterization of a photoacoustic imaging system optimized for rapid, high-resolution tomographic imaging of small animals. The system is based on a 128-element ultrasonic transducer array with a 5-MHz center frequency and 80% bandwidth shaped to a quarter circle of 25 mm radius. A 16-channel data-acquisition module and dedicated channel detection electronics enable capture of a 90-deg field-of-view image in less than 1 s and a complete 360-deg scan using sample rotation within 15 s. Measurements on cylindrical phantom targets demonstrate a resolution of better than 200 μm and high-sensitivity detection of 580-μm blood tubing to depths greater than 3 cm in a turbid medium with reduced scattering coefficient μs=7.8 cm-1. The system is used to systematically investigate the effects of target size, orientation, and geometry on tomographic imaging. As a demonstration of these effects and the system imaging capabilities, we present tomographic photoacoustic images of the brain vasculature of an ex vivo mouse with varying measurement aperture. For the first time, according to our knowledge, resolution of sub-200-μm vessels with an overlying turbid medium of greater than 2 cm depth is demonstrated using only intrinsic biological contrast.

Paper Details

Date Published: 1 March 2008
PDF: 10 pages
J. Biomed. Opt. 13(2) 024007 doi: 10.1117/1.2907157
Published in: Journal of Biomedical Optics Volume 13, Issue 2
Show Author Affiliations
John Kenneth Gamelin, Univ. of Connecticut (United States)
Andres Aquirre, Univ. of Connecticut (United States)
Anastasios Maurudis, Univ. of Connecticut (United States)
Fei Huang, Univ. of Connecticut (United States)
Diego Castillo, Univ. of Connecticut (United States)
Lihong V. Wang, Washington Univ. in St. Louis (United States)
Quing Zhu, Univ. of Connecticut (United States)

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