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Journal of Biomedical Optics • Open Access

Noninvasive Raman tomographic imaging of canine bone tissue
Author(s): Matthew V. Schulmerich; Jacqueline H. Cole; Kathryn A. Dooley; Michael D. Morris; Jaclynn Kreider; Steven A. Goldstein; Subhadra Srinivasan; Brian W. Pogue

Paper Abstract

Raman spectroscopic diffuse tomographic imaging has been demonstrated for the first time. It provides a noninvasive, label-free modality to image the chemical composition of human and animal tissue and other turbid media. This technique has been applied to image the composition of bone tissue within an intact section of a canine limb. Spatially distributed 785-nm laser excitation was employed to prevent thermal damage to the tissue. Diffuse emission tomography reconstruction was used, and the location that was recovered has been confirmed by micro-computed tomography (micro-CT) images.

Paper Details

Date Published: 1 March 2008
PDF: 3 pages
J. Biomed. Opt. 13(2) 020506 doi: 10.1117/1.2904940
Published in: Journal of Biomedical Optics Volume 13, Issue 2
Show Author Affiliations
Matthew V. Schulmerich, Univ. of Michigan (United States)
Jacqueline H. Cole, Univ. of Michigan (United States)
Kathryn A. Dooley, Univ. of Michigan (United States)
Michael D. Morris, Univ. of Michigan (United States)
Jaclynn Kreider, Univ. of Michigan Medical School (United States)
Steven A. Goldstein, Univ. of Michigan Medical School (United States)
Subhadra Srinivasan, Dartmouth College (United States)
Brian W. Pogue, Dartmouth College (United States)

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