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Journal of Biomedical Optics

Application of optical coherence tomography, pulsed photoacoustic technique, and time-of-flight technique to detect changes in the scattering properties of a tissue-simulating phantom
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Paper Abstract

Intralipid is a well-known emulsion used as a tissue-simulating phantom in developing optical imaging and diagnostic techniques for medical applications. The optical coherence tomography (OCT), pulsed photoacoustic (PA), and time-of-flight (TOF) techniques were used to detect glucose-induced changes in the optical properties of Intralipid. A comparison of the applicability of these techniques to register changes in the scattering properties of Intralipid samples showed that OCT is the most effective method, whereas the sensitivity of the PA technique was less pronounced. Photon migration studies with the TOF technique showed changes in pulse amplitude, pulse width, and arrival time of the pulse maximum as a function of changes in Intralipid concentration. Also the measured signal parameters showed changes when measuring high glucose concentrations.

Paper Details

Date Published: 1 March 2008
PDF: 9 pages
J. Biomed. Opt. 13(2) 024005 doi: 10.1117/1.2899152
Published in: Journal of Biomedical Optics Volume 13, Issue 2
Show Author Affiliations
Matti T. Kinnunen, Univ. of Oulu (Finland)
Risto A. Myllylä, Univ. of Oulu (Finland)

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