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Journal of Biomedical Optics

In vivo mice lung tumor follow-up with fluorescence diffuse optical tomography
Author(s): Anne Koeing; Lionel Herve; Véronique Josserand; Michel Berger; Jérôme Boutet; Anabela Da Silva; Jean-Marc Dinten; Philippe Peltie; Jean-Luc Coll; Philippe Rizo
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Paper Abstract

We present in vivo experiments conducted with a new fluorescence diffuse optical tomographic (fDOT) system on cancerous mice bearing mammary murine tumors. We first briefly present this new system that has been developed and its associated reconstruction method. Its main specificity is its ability to reconstruct the fluorescence yield even in heterogeneous and highly attenuating body regions such as lungs and to enable mouse inspection without immersion in optical index matching liquid (Intralipid and ink). Some phantom experiments validate the performance of this new system for heterogeneous media inspection. Its use for a mice study is then related. It consists in the follow-up of the lungs at different stages of tumor development after injection of RAFT-(cRGD)4-Alexa700. As expected, the reconstructed fluorescence increases along with the tumor stage. These results validate the use of our system for biological studies of small animals.

Paper Details

Date Published: 1 January 2008
PDF: 9 pages
J. Biomed. Opt. 13(1) 011008 doi: 10.1117/1.2884505
Published in: Journal of Biomedical Optics Volume 13, Issue 1
Show Author Affiliations
Anne Koeing, Lab. d'Electronique de Technologie de l'Information (France)
Lionel Herve, Lab. d'Electronique de Technologie de l'Information (France)
Véronique Josserand, ANIMAGE (France)
Michel Berger, Lab. d'Electronique de Technologie de l'Information (France)
Jérôme Boutet, Lab. d'Electronique de Technologie de l'Information (France)
Anabela Da Silva, Commissariat à l'Energie Atomique (France)
Jean-Marc Dinten, Lab. d'Electronique de Technologie de l'Information (France)
Philippe Peltie, Lab. d'Electronique de Technologie de l'Information (France)
Jean-Luc Coll, Institut Albert Bonniot (France)
Philippe Rizo, Lab. d'Electronique de Technologie de l'Information (France)


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