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Journal of Biomedical Optics • Open Access

Analysis of changes in reflectance measurements on biological tissues subjected to different probe pressures
Author(s): Roberto Reif; Mark S. Amorosino; Katherine W. Calabro; Ousama M. Aamar; Satish K. Singh; Irving J. Bigio

Paper Abstract

Spectral reflectance measurements of biological tissues have been studied for early diagnoses of several pathologies such as cancer. These measurements are often performed with a fiber optic probe in contact with the tissue surface. We report a study in which reflectance measurements are obtained in vivo from mouse thigh muscle while varying the contact pressure of the fiber optic probe. It is determined that the probe pressure is a variable that affects the local optical properties of the tissue. The reflectance spectra are analyzed with an analytical model that extracts the tissue optical properties and facilitates the understanding of underlying physiological changes induced by the probe pressure.

Paper Details

Date Published: 1 January 2008
PDF: 3 pages
J. Biomed. Opt. 13(1) 010502 doi: 10.1117/1.2870115
Published in: Journal of Biomedical Optics Volume 13, Issue 1
Show Author Affiliations
Roberto Reif, Boston Univ. (United States)
Mark S. Amorosino, Boston Medical Ctr. (United States)
Katherine W. Calabro, Boston Univ. (United States)
Ousama M. Aamar, Boston Univ. (United States)
Satish K. Singh, Boston Medical Ctr. (United States)
Irving J. Bigio, Boston Univ. (United States)


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