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Journal of Biomedical Optics

Optical microcirculatory skin model: assessed by Monte Carlo simulations paired with in vivo laser Doppler flowmetry
Author(s): Ingemar Fredriksson; Marcus Larsson; Tomas Strömberg
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Paper Abstract

An optical microvascular skin model, valid at 780 nm, was developed. The model consisted of six layers with individual optical properties and variable thicknesses and blood concentrations at three different blood flow velocities. Monte Carlo simulations were used to evaluate the impact of various model parameters on the traditional laser Doppler flowmetry (LDF) measures. A set of reference Doppler power spectra was generated by simulating 7000 configurations, varying the thickness and blood concentrations. Simulated spectra, at two different source detector separations, were compared with in vivo recorded spectra, using a nonlinear search algorithm for minimizing the deviation between simulated and measured spectra. The model was validated by inspecting the thickness and blood concentrations that generated the best fit. These four parameters followed a priori expectations for the measurement situations, and the simulated spectra agreed well with the measured spectra for both detector separations. Average estimated dermal blood concentration was 0.08% at rest and 0.63% during heat provocation (44 °C) on the volar side of the forearm and 1.2% at rest on the finger pulp. The model is crucial for developing a technique for velocity-resolved absolute LDF measurements with known sampling volume and can also be useful for other bio-optical modalities.

Paper Details

Date Published: 1 January 2008
PDF: 12 pages
J. Biomed. Opt. 13(1) 014015 doi: 10.1117/1.2854691
Published in: Journal of Biomedical Optics Volume 13, Issue 1
Show Author Affiliations
Ingemar Fredriksson, Linköpings Univ. (Sweden)
Marcus Larsson, Linköpings Univ. (Sweden)
Tomas Strömberg, Linköpings Univ. (Sweden)

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