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Journal of Biomedical Optics

Shape factor analysis of progressive rat hepatoma images
Author(s): William B. Spillman; John Robertson; Kenith E. Meissner; Justin Jesselli; J. Daniel Bourland; Michael C. Robbins; Edward G. Shaw
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Paper Abstract

We explore the hypothesis that shape factors can be used as tools to probe disease progression in addition to being used for simple classification. We define and apply a new shape factor to digital images of tumor cross sections of progressive rat hepatoma. Using a number of standard pathological measures, each image is also associated with a "disease time," a continuous variable between 0 and 1 with 0 being disease initiation and 1 being a near-fatal condition. The images are converted to data files that represent the 2-D shapes of the tumors. Their shape factors are then determined and plotted versus disease time. The results show that the shape factor can indicate and localize the tumor structural phase transition that occurs between uniform growth and infiltration.

Paper Details

Date Published: 1 January 2008
PDF: 8 pages
J. Biomed. Opt. 13(1) 014030 doi: 10.1117/1.2841020
Published in: Journal of Biomedical Optics Volume 13, Issue 1
Show Author Affiliations
William B. Spillman, NanoSonic, Inc. (United States)
John Robertson, Virginia Polytechnic Institute and State Univ. (United States)
Kenith E. Meissner, Texas A&M Univ. (United States)
Justin Jesselli, Virginia Polytechnic Institute and State Univ. (United States)
J. Daniel Bourland, Wake Forest Univ. (United States)
Michael C. Robbins, Wake Forest Univ. (United States)
Edward G. Shaw, Wake Forest Univ. (United States)

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