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Journal of Biomedical Optics • Open Access

Determination of the optical properties of turbid media using relative interstitial radiance measurements: Monte Carlo study, experimental validation, and sensitivity analysis
Author(s): Lee C. L. Chin; Arthur E. Worthington; William M. Whelan; I. Alex Vitkin

Paper Abstract

Interstitial quantification of the optical properties of tissue is important in biomedicine for both treatment planning of minimally invasive laser therapies and optical spectroscopic characterization of tissues, for example, prostate cancer. In a previous study, we analyzed a method first demonstrated by Dickey et al., [Phys. Med. Biol. 46, 2359 (2001)] to utilize relative interstitial steady-state radiance measurements for recovering the optical properties of turbid media. The uniqueness of point radiance measurements were demonstrated in a forward sense, and strategies were suggested for improving performance under noisy experimental conditions. In this work, we test our previous conclusions by fitting the P3 approximation for radiance to Monte Carlo predictions and experimental data in tissue-simulating phantoms. Fits are performed at: 1. a single sensor position (0.5 or 1 cm), 2. two sensor positions (0.5 and 1 cm), and 3. a single sensor position (0.5 or 1 cm) with input knowledge of the sample's effective attenuation coefficient. The results demonstrate that single sensor radiance measurements can be used to retrieve optical properties to within ~20%, provided the transport albedo is greater than ~0.9. Furthermore, compared to the single sensor fits, employing radiance data at two sensor positions did not significantly improve the accuracy of recovered optical properties. However, with knowledge of the effective attenuation coefficient of the medium, optical properties can be retrieved experimentally to within ~10% for an albedo greater or equal to 0.5.

Paper Details

Date Published: 1 November 2007
PDF: 13 pages
J. Biomed. Opt. 12(6) 064027 doi: 10.1117/1.2821406
Published in: Journal of Biomedical Optics Volume 12, Issue 6
Show Author Affiliations
Lee C. L. Chin, Princess Margaret Hospital (United States)
Arthur E. Worthington, Ryerson Univ. (Canada)
William M. Whelan, Univ. of Prince Edward Island (Canada)
I. Alex Vitkin, Univ. Health Network (Canada)

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