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Journal of Biomedical Optics • Open Access

Deep reflection-mode photoacoustic imaging of biological tissue

Paper Abstract

A reflection-mode photoacoustic (PA) imaging system was designed and built to image deep structures in biological tissues. We chose near-infrared laser pulses of 804-nm wavelength for PA excitation to achieve deep penetration. To minimize unwanted surface signals, we adopted dark-field ring-shaped illumination. This imaging system employing a 5-MHz spherically focused ultrasonic transducer provides penetration up to 38 mm in chicken breast tissue. At the 19-mm depth, the axial resolution is 144 μm and the transverse resolution is 560 μm. Internal organs of small animals were imaged clearly.

Paper Details

Date Published: 1 November 2007
PDF: 3 pages
J. Biomed. Opt. 12(6) 060503 doi: 10.1117/1.2818045
Published in: Journal of Biomedical Optics Volume 12, Issue 6
Show Author Affiliations
Kwanghyun Song, Washington Univ. in St. Louis (United States)
Lihong V. Wang, Washington Univ. in St. Louis (United States)


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