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Journal of Biomedical Optics

Time-resolved diffuse optical tomography and its application to in vitro and in vivo imaging
Author(s): Huijuan Zhao; Feng Gao; Yukari Tanikawa; Yukio Yamada
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Paper Abstract

This work reviews our research during the past several years on time-resolved (TR) near-infrared diffuse optical tomography (DOT). Following an introduction of the measuring modes, two proposed schemes of image reconstruction in TR-DOT are described: one utilizes the full TR data, and the other, referred to as the modified generalized pulse spectrum technique (GPST), uses the featured data extracted from the TR measurement. The performances of the two algorithms in quantitativeness and spatial resolution are comparatively investigated with 2-D simulated data. TR-DOT images are then presented for phantom experiments, which are obtained by using a 16-channel time-correlated single photon counting system, and the factors affecting the quantification of the reconstruction are discussed. Finally, in vitro and in vivo imaging examples are illustrated for validating the capibility of TR-DOT to provide not only the anatomical but also the physiological information of the objects.

Paper Details

Date Published: 1 November 2007
PDF: 13 pages
J. Biomed. Opt. 12(6) 062107 doi: 10.1117/1.2815724
Published in: Journal of Biomedical Optics Volume 12, Issue 6
Show Author Affiliations
Huijuan Zhao, Tianjin Univ. (China)
Feng Gao, Tianjin Univ. (China)
Yukari Tanikawa, National Institute of Advanced Industrial Science and Technology (Japan)
Yukio Yamada, The Univ. of Electro-Communications (Japan)


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