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Journal of Biomedical Optics • Open Access

Optoacoustic imaging based on the interferometric measurement of surface displacement

Paper Abstract

We present images of tissue phantoms and chicken chorio-allantoic membrane vasculature using a novel optoacoustic tomography technique based on the time-resolved interferometric measurement of laser-induced thermoelastic expansion. Our imaging system is based on a modified Mach-Zehnder interferometer that provides surface displacement measurements with a temporal resolution of 4 ns and a displacement sensitivity of 0.3 nm. The images are reconstructed from surface displacement measurements made at several locations following irradiation of the sample with Q-switched Nd:YAG (λ=532, 1064 nm) laser pulses using a delay and sum beam-forming algorithm. The images shown demonstrate the ability of our method to provide better than 200-μm lateral and 30-μm axial resolution at depths exceeding ten transport mean free paths in highly scattering in-vitro and in-vivo model systems.

Paper Details

Date Published: 1 November 2007
PDF: 9 pages
J. Biomed. Opt. 12(6) 064001 doi: 10.1117/1.2812665
Published in: Journal of Biomedical Optics Volume 12, Issue 6
Show Author Affiliations
Stefan A. Carp, Univ. of California/Irvine (United States)
Vasan Venugopalan, Univ. of California/Irvine (United States)

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