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Journal of Biomedical Optics

Tissue birefringence of hypercholesterolemic rat liver measured with polarization-sensitive optical coherence tomography
Author(s): Chau-Chung Wu; Yih-Ming Wang; Long-Sheng Lu; Chia-Wei Sun; Chih-Wei Lu; Meng-Tsan Tsai; Chih-Chung Yang
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Paper Abstract

We measure in vitro tissue birefringence in the liver of hypercholesterolemic rats with polarization-sensitive optical coherence tomography. Tissue birefringence is determined by measuring the phase retardation as a function of tissue depth. The birefringence of such a sample is usually due to the narrow fibrous structures that cannot be resolved by a standard optical coherence tomography system. Anisotropic structures are formed in the hypercholesterolemic rat liver, which is quite different from the isotropic nature of healthy liver. Birefringence is evaluated to give an order of magnitude of 4.48×10-4 at 790 nm in hypercholesterolemic rat liver. The infiltration of macrophages and increased collagen deposition should be major causes for tissue birefringence in hypercholesterolemic liver.

Paper Details

Date Published: 1 November 2007
PDF: 5 pages
J. Biomed. Opt. 12(6) 064022 doi: 10.1117/1.2812647
Published in: Journal of Biomedical Optics Volume 12, Issue 6
Show Author Affiliations
Chau-Chung Wu, National Taiwan Univ. Hospital (Taiwan)
Yih-Ming Wang, National Taiwan Univ. (Taiwan)
Long-Sheng Lu, National Taiwan Univ. (Taiwan)
Chia-Wei Sun, Industrial Technology Research Institute (Taiwan)
Chih-Wei Lu, National Taiwan Univ. (Taiwan)
Meng-Tsan Tsai, National Taiwan Univ. (Taiwan)
Chih-Chung Yang, National Taiwan Univ. (Taiwan)


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