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Journal of Biomedical Optics • Open Access

Clinical evaluation of time-resolved spectroscopy by measuring cerebral hemodynamics during cardiopulmonary bypass surgery
Author(s): Etsuko Ohmae; Motoki Oda; Toshihiko Suzuki; Yutaka Yamashita; Yasuyuki Kakihana; Akira Matsunaga; Yuichi Kanmura; Mamoru Tamura

Paper Abstract

We developed a three-wavelength time-resolved spectroscopy (TRS) system, which allows quantitative measurement of hemodynamics within relatively large living tissue. We clinically evaluated this TRS system by monitoring cerebral circulation during cardiopulmonary bypass surgery. Oxyhemoglobin, deoxyhemoglobin, total hemoglobin and oxygen saturation (SO2) were determined by TRS on the left forehead attached with an optode spacing of 4 cm. We also simultaneously monitored jugular venous oxygen saturation (SjvO2) and arterial blood hematocrit (Hct) using conventional methods. The validity and usefulness of the TRS system were assessed by comparing parameters obtained with the TRS and conventional methods. Although the changes in SO2 were lower than those in SjvO2, SO2 obtained by TRS paralleled the fluctuations in SjvO2, and a good correlation between these values was observed. The only exceptions occurred during the perfusion period. Moreover, there was a good correlation between tHb and Hct values (r2=0.63). We concluded that time-resolved spectroscopy reflected the conditions of cerebral hemodynamics of patients during surgical operations.

Paper Details

Date Published: 1 November 2007
PDF: 9 pages
J. Biomed. Opt. 12(6) 062112 doi: 10.1117/1.2804931
Published in: Journal of Biomedical Optics Volume 12, Issue 6
Show Author Affiliations
Etsuko Ohmae, Hamamatsu Photonics K.K. (Japan)
Motoki Oda, Hamamatsu Photonics K.K. (Japan)
Toshihiko Suzuki, Hamamatsu Photonics K.K. (Japan)
Yutaka Yamashita, Hamamatsu Photonics K.K. (Japan)
Yasuyuki Kakihana, Kagoshima Univ. Hospital (Japan)
Akira Matsunaga, Kagoshima Univ. Hospital (Japan)
Yuichi Kanmura, Kagoshima Univ. Hospital (Japan)
Mamoru Tamura, Hokkaido Univ. (Japan)

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