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Journal of Biomedical Optics

Delivery of fluorescent probes using iron oxide particles as carriers enables in-vivo labeling of migrating neural precursors for magnetic resonance imaging and optical imaging
Author(s): James P. Sumner; Richard Conroy; Erik Shapiro; John Moreland; Alan P. Koretsky
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Paper Abstract

Iron oxide particles are becoming an important contrast agent for magnetic resonance imaging (MRI) cell tracking studies. Simultaneous delivery of fluorescence indicators with the particles to individual cells offers the possibility of correlating optical images and MRI. In this work, it is demonstrated that micron-sized iron oxide particles (MPIOs) can be used as a carrier to deliver fluorescent probes to cells in culture as well as to migrating neural progenitors in vivo. Migrating progenitors were tracked with MRI and easily identified by histology because of the fluorescent probe. These data suggest that using MPIOs to deliver fluorescent probes should make it possible to combine MRI and optical imaging for in vivo cell tracking.

Paper Details

Date Published: 1 September 2007
PDF: 6 pages
J. Biomed. Opt. 12(5) 051504 doi: 10.1117/1.2800294
Published in: Journal of Biomedical Optics Volume 12, Issue 5
Show Author Affiliations
James P. Sumner, National Institutes of Health (United States)
Richard Conroy, National Institutes of Health (United States)
Erik Shapiro, Yale Univ. (United States)
John Moreland, National Institute of Standards and Technology (United States)
Alan P. Koretsky, National Institutes of Health (United States)

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