Share Email Print

Journal of Biomedical Optics

Digital mouse phantom for optical imaging
Format Member Price Non-Member Price
PDF $20.00 $25.00
cover GOOD NEWS! Your organization subscribes to the SPIE Digital Library. You may be able to download this paper for free. Check Access

Paper Abstract

We present a method for design and use of a digital mouse phantom for small animal optical imaging. We map the boundary of a mouse model from magnetic resonance imaging (MRI) data through image processing algorithms and discretize the geometry by a finite element (FE) descriptor. We use a validated FE implementation of the three-dimensional (3-D) diffusion equation to model transport of near infrared (NIR) light in the phantom with a mesh resolution optimized for representative tissue optical properties on a computing system with 8-GB RAM. Our simulations demonstrate that a section of the mouse near the light source is adequate for optical system design and that the variation of intensity of light on the boundary is well within typical noise levels for up to 20% variation in optical properties and nodes used to model the boundary of the phantom. We illustrate the use of the phantom in setting goals for specific binding of targeted exogenous fluorescent contrasts based on anatomical location by simulating a nearly tenfold change in the detectability of a 2-mm-deep target depending on its placement. The methodology described is sufficiently general and may be extended to generate digital phantoms for designing clinical optical imaging systems.

Paper Details

Date Published: 1 September 2007
PDF: 8 pages
J. Biomed. Opt. 12(5) 051804 doi: 10.1117/1.2800033
Published in: Journal of Biomedical Optics Volume 12, Issue 5
Show Author Affiliations
Shekhar Dwivedi, GE Global Research - JFWTC (India)
Kajoli B. Krishnan, GE Global Research - JFWTC (India)
Srikanth Suryanarayanan, GE India Technology Ctr. (India)

© SPIE. Terms of Use
Back to Top