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Journal of Biomedical Optics

Dynamic optical imaging of vascular and metabolic reactivity in rheumatoid joints
Author(s): Joseph M. Lasker; Christopher J. Fong; Daniel T. Ginat; Edward Dwyer; Andreas H. Hielscher
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Paper Abstract

Dynamic optical imaging is increasingly applied to clinically relevant areas such as brain and cancer imaging. In this approach, some external stimulus is applied and changes in relevant physiological parameters (e.g., oxy- or deoxyhemoglobin concentrations) are determined. The advantage of this approach is that the prestimulus state can be used as a reference or baseline against which the changes can be calibrated. Here we present the first application of this method to the problem of characterizing joint diseases, especially effects of rheumatoid arthritis (RA) in the proximal interphalangeal finger joints. Using a dual-wavelength tomographic imaging system together with previously implemented model-based iterative image reconstruction schemes, we have performed initial dynamic imaging case studies on a limited number of healthy volunteers and patients diagnosed with RA. Focusing on three cases studies, we illustrated our major finds. These studies support our hypothesis that differences in the vascular reactivity exist between affected and unaffected joints.

Paper Details

Date Published: 1 September 2007
PDF: 13 pages
J. Biomed. Opt. 12(5) 052001 doi: 10.1117/1.2798757
Published in: Journal of Biomedical Optics Volume 12, Issue 5
Show Author Affiliations
Joseph M. Lasker, Schick Technologies Inc. (United States)
Christopher J. Fong, Columbia Univ. (United States)
Daniel T. Ginat, Columbia Univ. (United States)
Edward Dwyer, Columbia Univ. (United States)
Andreas H. Hielscher, Columbia Univ. (United States)

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