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Journal of Biomedical Optics

Diffuse optical monitoring of blood flow and oxygenation in human breast cancer during early stages of neoadjuvant chemotherapy
Author(s): Chao Zhou; Regine Choe; Natasha S. Shah; Turgut Durduran; Guoqiang Yu; Amanda Durkin; David Hsiang; Rita Mehta; John A. Butler; Albert E. Cerussi; Bruce Jason Tromberg; Arjun G. Yodh
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Paper Abstract

We combine diffuse optical spectroscopy (DOS) and diffuse correlation spectroscopy (DCS) to noninvasively monitor early hemodynamic response to neoadjuvant chemotherapy in a breast cancer patient. The potential for early treatment monitoring is demonstrated. Within the first week of treatment (day 7) DOS revealed significant changes in tumor/normal contrast compared to pretreatment (day 0) tissue concentrations of deoxyhemoglobin (rctHHbT/N=69±21%), oxyhemoglobin (rctO2HbT/N=73±25%), total hemoglobin (rctTHbT/N=72±17%), and lipid concentration (rctLipidT/N=116±13%). Similarly, DCS found significant changes in tumor/normal blood flow contrast (rBFT/N=75±7% on day 7 with respect to day 0). Our observations suggest the combination of DCS and DOS enhances treatment monitoring compared to either technique alone. The hybrid approach also enables construction of indices reflecting tissue metabolic rate of oxygen, which may provide new insights about therapy mechanisms.

Paper Details

Date Published: 1 September 2007
PDF: 11 pages
J. Biomed. Opt. 12(5) 051903 doi: 10.1117/1.2798595
Published in: Journal of Biomedical Optics Volume 12, Issue 5
Show Author Affiliations
Chao Zhou, Univ. of Pennsylvania (United States)
Regine Choe, Univ. of Pennsylvania (United States)
Natasha S. Shah, Univ. of California/Irvine (United States)
Turgut Durduran, Univ. of Pennsylvania (United States)
Guoqiang Yu, Univ. of Pennsylvania (United States)
Amanda Durkin, Univ. of California/Irvine (United States)
David Hsiang, Univ. of California/Irvine (United States)
Rita Mehta, Univ. of California/Irvine (United States)
John A. Butler, Univ. of California/Irvine (United States)
Albert E. Cerussi, Beckman Laser Institute and Medical Clinic (United States)
Bruce Jason Tromberg, Beckman Laser Institute and Medical Clinic (United States)
Arjun G. Yodh, Univ. of Pennsylvania (United States)


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