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Journal of Biomedical Optics

Sensitive biosensor array using surface plasmon resonance on metallic nanoslits
Author(s): Kuang-Li Lee; Chia-Wei Lee; Way-Seen Wang; Pei-Kuan Wei
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Paper Abstract

Chip-based biosensor arrays for label-free and high-throughput detection were fabricated and tested. The sensor array was composed of a 150-nm-thick, 50-nm-gap, and 600-nm-period gold nanoslits. Each array size was 100 μm×100 μm. A transverse-magnetic polarized wave in these metallic nanostructures generated resonant surface plasmons at a wavelength of about 800 nm in a water environment. Using the resonant wavelength shift in the nanoslit array, we achieved detection sensitivity up to 668 nm per refractive index unit, about 1.7 times larger than that reported on an array of nanoholes. An antigen–antibody interaction experiment in an aqueous environment verified the sensitivity in a surface binding event.

Paper Details

Date Published: 1 July 2007
PDF: 5 pages
J. Biomed. Opt. 12(4) 044023 doi: 10.1117/1.2772296
Published in: Journal of Biomedical Optics Volume 12, Issue 4
Show Author Affiliations
Kuang-Li Lee, Academia Sinica (Taiwan)
Chia-Wei Lee, Research Ctr. for Applied Sciences (Taiwan)
Way-Seen Wang, National Taiwan Univ. (Taiwan)
Pei-Kuan Wei, Academia Sinica (Taiwan)

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