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Journal of Biomedical Optics • Open Access

Targeting spectral signatures of progressively dysplastic stratified epithelia using angularly variable fiber geometry in reflectance Monte Carlo simulations
Author(s): Adrien Ming Jer Wang; Vengadesan Nammalvar; Rebekah Anna Drezek

Paper Abstract

A key component of accurate spectroscopic-based cancer diagnostics is the ability to differentiate spectral variations resulting from epithelial tissue dysplasia. Such measurement may be enhanced by discretely probing the optical properties of the epithelial tissue where the morphological and biochemical features vary according to tissue depths. More precisely, layer-specific changes in tissue optical properties correlated to cellular dysplasia can be determined by conventional reflectance spectroscopy when it is coupled with angularly variable fiber geometry. Thus, this study addresses how angularly variable fiber geometry can resolve spatially specific spectral signatures of tissue pathology by interpreting and analyzing the reflectance spectra of increasingly dysplastic epithelial tissue in reflectance-mode Monte Carlo simulation. Specifically, by increasing the obliquity of the collection fibers from 0 to 40 deg in the direction facing toward the illumination fiber, the spectral sensitivity to tissue abnormalities in the epithelial layer is thereby improved, whereas orthogonal fibers are more sensitive to the changes in the stromal layer.

Paper Details

Date Published: 1 July 2007
PDF: 14 pages
J. Biomed. Opt. 12(4) 044012 doi: 10.1117/1.2769328
Published in: Journal of Biomedical Optics Volume 12, Issue 4
Show Author Affiliations
Adrien Ming Jer Wang, Rice Univ. (United States)
Vengadesan Nammalvar, Rice Univ. (United States)
Rebekah Anna Drezek, Rice Univ. (United States)

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