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Journal of Biomedical Optics • Open Access

Three-dimensional nonlinear optical endoscopy
Author(s): Ling Fu; Ankur Jain; Charles Cranfield; Huikai Xie; Min Gu

Paper Abstract

The development of miniaturized nonlinear optical microscopy or endoscopy is essential to complement the current imaging modalities for diagnosis and monitoring of cancers. We report on a nonlinear optical endoscope based on a double-clad photonic crystal fiber and a two-dimensional (2-D) microelectromechanical system mirror, enabling the three-dimensional (3-D) nonlinear optical imaging through in vitro gastrointestinal tract tissue and human breast cancer tissue with a penetration depth of approximately 100 μm and axial resolution of 10 μm. The 3-D high-resolution and high-sensitive imaging ability of the nonlinear optical endoscope facilitates the visualization of 3-D morphologic and cell nuclei arrangement within tissue, and therefore will be important for histopathologic interpretation without the need of tissue excision.

Paper Details

Date Published: 1 July 2007
PDF: 3 pages
J. Biomed. Opt. 12(4) 040501 doi: 10.1117/1.2756102
Published in: Journal of Biomedical Optics Volume 12, Issue 4
Show Author Affiliations
Ling Fu, Swinburne Univ. of Technology (Australia)
Ankur Jain, Univ. of Florida (United States)
Charles Cranfield, Swinburne Univ. of Technology (Australia)
Huikai Xie, Univ. of Florida (United States)
Min Gu, Swinburne Univ. of Technology (Australia)

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