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Journal of Biomedical Optics

Three-dimensional panoramic imaging of cardiac arrhythmias in rabbit heart
Author(s): Fujian Qu; Crystal M. Ripplinger; Vladimir Nikolski; Cindy Grimm; Igor R. Efimov
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Paper Abstract

Cardiac fluorescent optical imaging provides the unique opportunity to investigate the dynamics of propagating electrical waves during ventricular arrhythmias and the termination of arrhythmias by strong electric shocks. Panoramic imaging systems using charge-coupled device (CCD) cameras as the photodetector have been developed to overcome the inability to monitor electrical activity from the entire cardiac surface. Photodiode arrays (PDAs) are known to have higher temporal resolution and signal quality, but lower spatial resolution compared to CCD cameras. We construct a panoramic imaging system with three PDAs and image Langendorff perfused rabbit hearts (n=18) during normal sinus rhythm, epicardial pacing, and arrhythmias. The recorded spatiotemporal dynamics of electrical activity is texture mapped onto a reconstructed 3-D geometrical heart model specific to each heart studied. The PDA-based system provides sufficient spatial resolution (1.72 mm without interpolation) for the study of wavefront propagation in the rabbit heart. The reconstructed 3-D electrical activity provides us with a powerful tool to investigate the fundamental mechanisms of arrhythmia maintenance and termination.

Paper Details

Date Published: 1 July 2007
PDF: 9 pages
J. Biomed. Opt. 12(4) 044019 doi: 10.1117/1.2753748
Published in: Journal of Biomedical Optics Volume 12, Issue 4
Show Author Affiliations
Fujian Qu, Washington Univ. in St. Louis (United States)
Crystal M. Ripplinger, Washington Univ. in St. Louis (United States)
Vladimir Nikolski, Case Western Reserve Univ. (United States)
Cindy Grimm, Washington Univ. in St. Louis (United States)
Igor R. Efimov, Case Western Reserve Univ. (United States)

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