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Journal of Biomedical Optics

Theoretical and practical considerations on detection performance of time domain, Fourier domain, and swept source optical coherence tomography
Author(s): Bin Liu; Mark E. Brezinski
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Paper Abstract

Optical coherence tomography (OCT) based on spectral interferometry has recently been examined, with authors often suggesting superior performance compared with time domain approaches. The technologies have similar resolutions and the spectral techniques may currently claim faster acquisition rates. Contrary to many current opinions, their detection parameters may be inferior. The dynamic range and signal-to-noise ratio (SNR) correlate with image penetration, the contrast as a function of depth. This work examines the theoretical sensitivity, dynamic range, and SNR of the techniques, within the practical limits of optoelectronics, taking into account often ignored or misunderstood classical factors that affect performance, such as low frequency noise, analog to digital (AD) conversion losses, and methods for potentially improving sensitivity, including fast laser sweeping. The technologies are compared relative to these parameters. While Fourier domain OCT has some advantages such as signal integration, it appears unlikely that its disadvantages can ultimately be overcome for nontransparent tissue. Ultimately, time-domain (TD)-OCT appears to have the superior performance with respect to SNR and dynamic range. This may not be the case for transparent tissue of the eye. Certain positive aspects of swept source OCT leave the possibility open that its performance may approach that of (TD)-OCT in nontransparent tissue.

Paper Details

Date Published: 1 July 2007
PDF: 12 pages
J. Biomed. Opt. 12(4) 044007 doi: 10.1117/1.2753410
Published in: Journal of Biomedical Optics Volume 12, Issue 4
Show Author Affiliations
Bin Liu, Brigham and Women's Hospital (United States)
Mark E. Brezinski, Brigham and Women's Hospital (United States)


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