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Journal of Biomedical Optics

In vivo bladder imaging with microelectromechanical-systems-based endoscopic spectral domain optical coherence tomography
Author(s): Zhenguo Wang; Christopher S. D. Lee; Wayne C. Waltzer; Jingxuan Liu; Huikai Xie; Zhijia Yuan; Yingtian Pan
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Paper Abstract

We report the recent technical improvements in our microelectromechanical systems (MEMS)-based spectral-domain endoscopic OCT (SDEOCT) and applications for in vivo bladder imaging diagnosis. With the technical advances in MEMS mirror fabrication and endoscopic light coupling methods, the new SDEOCT system is able to visualize morphological details of the urinary bladder with high image fidelity close to bench-top OCT (e.g., 10 μm/12 μm axial/lateral resolutions, gap;108 dB dynamic range) at a fourfold to eightfold improved frame rate. An in vivo animal study based on a porcine acute inflammation model following protamine sulfate instillation is performed to further evaluate the utility of SDEOCT system to delineate bladder morphology and inflammatory lesions as well as to detect subsurface blood flow. In addition, a preliminary clinical study is performed to identify the morphological features pertinent to bladder cancer diagnosis, including loss of boundary or image contrast between urothelium and the underlying layers, heterogeneous patterns in the cancerous urothelium, and margin between normal and bladder cancers. The results of a human study (91% sensitivity, 80% specificity) suggest that SDEOCT enables a high-resolution cross-sectional image of human bladder structures to detect transitional cell carcinomas (TCC); however, due to reduced imaging depth of SDEOCT in cancerous lesions, staging of bladder cancers may be limited to T1 to T2a (prior to muscle invasion).

Paper Details

Date Published: 1 May 2007
PDF: 8 pages
J. Biomed. Opt. 12(3) 034009 doi: 10.1117/1.2749744
Published in: Journal of Biomedical Optics Volume 12, Issue 3
Show Author Affiliations
Zhenguo Wang, Stony Brook Univ. (United States)
Christopher S. D. Lee, Stony Brook Univ. (United States)
Wayne C. Waltzer, Stony Brook Univ. (United States)
Jingxuan Liu, Stony Brook Univ. (United States)
Huikai Xie, Univ. of Florida (United States)
Zhijia Yuan, State Univ. of New York/Stony Brook (United States)
Yingtian Pan, Stony Brook Univ. (United States)

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