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Journal of Biomedical Optics

Detection of the presence of antibodies against Toxoplasma gondii in human colostrum by Raman spectroscopy and principal component analysis
Author(s): C. Araujo-Andrade; Juan L. Pichardo-Molina; G. Barbosa-Sabanero; C. Frausto-Reyes; A. Torres-Lopez
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Paper Abstract

More than 60 million people in the United States and 23 million people in Mexico probably are infected with the Toxoplasma parasite, but very few have symptoms because the immune system usually keeps the parasite from causing illness. However, for people whose immune system is compromised, the consequences can be fatal. Toxoplasmosis is detected indirectly by different serological tests, where the sample requires a previous preparation. We analyze the feasibility to use Raman spectroscopy and principal component analysis (PCA) as an alternative method to detect the presence or absence of antibodies IgG (immunoglobulin G), IgM (immunoglobulin M), and IgA (immunoglobulin A), against Toxoplasma gondii, in a simple and fast way, in samples of human colostrum from a group of volunteers who were in contact with the parasite and others who were not in contact with the parasite.

Paper Details

Date Published: 1 May 2007
PDF: 5 pages
J. Biomed. Opt. 12(3) 034006 doi: 10.1117/1.2749740
Published in: Journal of Biomedical Optics Volume 12, Issue 3
Show Author Affiliations
C. Araujo-Andrade, Ctr. de Investigaciones en Óptica, A.C. (Mexico)
Juan L. Pichardo-Molina, Ctr. de Investigaciones en Óptica, A.C. (Mexico)
G. Barbosa-Sabanero, Univ. de Guanajuato (Mexico)
C. Frausto-Reyes, Ctr. de Investigaciones en Óptica A.C. (Mexico)
A. Torres-Lopez, Univ. de Guanajuato (Mexico)

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