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Journal of Biomedical Optics

Performance of an exhaled nitric oxide and carbon dioxide sensor using quantum cascade laser-based integrated cavity output spectroscopy
Author(s): Matthew R. McCurdy; Yury A. Bakhirkin; Gerard Wysocki; Frank K. Tittel
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Paper Abstract

Exhaled nitric oxide (NO) is an important biomarker in asthma and other respiratory disorders. The optical performance of a NO/CO2 sensor employing integrated cavity output spectroscopy (ICOS) with a quantum cascade laser operating at 5.22 μm capable of real-time NO and CO2 measurements in a single breath cycle is reported. A NO noise-equivalent concentration of 0.4 ppb within a 1-sec integration time is achieved. The off-axis ICOS sensor performance is compared to a chemiluminescent NO analyzer and a nondispersive infrared (NDIR) CO2 absorption capnograph. Differences between the gas analyzers are assessed by the Bland-Altman method to estimate the expected variability between the gas sensors. The off-axis ICOS sensor measurements are in good agreement with the data acquired with the two commercial gas analyzers. This work demonstrates the performance characteristics and merits of mid-infrared spectroscopy for exhaled breath analysis.

Paper Details

Date Published: 1 May 2007
PDF: 9 pages
J. Biomed. Opt. 12(3) 034034 doi: 10.1117/1.2747608
Published in: Journal of Biomedical Optics Volume 12, Issue 3
Show Author Affiliations
Matthew R. McCurdy, Rice Univ. (United States)
Yury A. Bakhirkin, Rice Univ. (United States)
Gerard Wysocki, Rice Univ. (United States)
Frank K. Tittel, Rice Univ. (United States)

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