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Journal of Biomedical Optics • Open Access

Qualitative assessment of undetectable melanin distribution in lightly pigmented irides
Author(s): Gladimir V.G. Baranoski; Michael W.Y. Lam

Paper Abstract

A longstanding issue in biomedical research concerns the biophysical factors affecting the color diversity of the human irides and its connection with ocular diseases. Although the pigmentation and morphological characteristics of heavily and moderately pigmented irides have been extensively discussed in the literature, similar studies are scarce for lightly pigmented irides. We present computer experiments indicating that the spectral signature of these specimens may be directly affected by still undetectable melanin distributions in the outermost iridal layers. Our findings represent in silico evidence of this relationship which, in turn, may have implications in the investigation of the higher risk of death from metastatic ocular melanoma verified in individuals with light-colored irides.

Paper Details

Date Published: 1 May 2007
PDF: 3 pages
J. Biomed. Opt. 12(3) 030501 doi: 10.1117/1.2747205
Published in: Journal of Biomedical Optics Volume 12, Issue 3
Show Author Affiliations
Gladimir V.G. Baranoski, Univ. of Waterloo (Canada)
Michael W.Y. Lam, Univ. of Waterloo (Canada)

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