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Journal of Biomedical Optics • Open Access

Optical method for real-time monitoring of drug concentrations facilitates the development of novel methods for drug delivery to brain tissue
Author(s): Roberto Reif; Mei Wang; Shailendra Joshi; Ousama M. Aamar; Irving J. Bigio

Paper Abstract

The understanding of drug delivery to organs, such as the brain, has been hampered by the inability to measure tissue drug concentrations in real time. We report an application of an optical spectroscopy technique that monitors in vivo the real-time drug concentrations in small volumes of brain tissue. This method will facilitate development of new protocols for delivery of drugs to treat brain cancers. The delivery of many anticancer drugs to the brain is limited by the presence of the blood-brain barrier (BBB). Mitoxantrone (MTX) is a water-soluble anticancer drug that poorly penetrates the BBB. It is preliminarily determined in an animal model that the brain tissue uptake of chemotherapy agents—in this demonstration, MTX—delivered intra-arterially is enhanced when the BBB is disrupted.

Paper Details

Date Published: 1 May 2007
PDF: 5 pages
J. Biomed. Opt. 12(3) 034036 doi: 10.1117/1.2744025
Published in: Journal of Biomedical Optics Volume 12, Issue 3
Show Author Affiliations
Roberto Reif, Boston Univ. (United States)
Mei Wang, Columbia Univ. (United States)
Shailendra Joshi, Columbia Univ. (United States)
Ousama M. Aamar, Boston Univ. (United States)
Irving J. Bigio, Boston Univ. (United States)

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