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Journal of Biomedical Optics

Time-resolved optical imager for assessment of cerebral oxygenation
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Paper Abstract

A time-resolved optical instrument allowing for noninvasive assessment of cerebral oxygenation is presented. The instrument is equipped with picosecond diode lasers, fast photodetectors, and time-correlated single photon counting electronics. This technology enables depth-resolved estimation of changes in absorption and, in consequence, assessment of changes in hemoglobin concentrations in the brain cortex. Changes in oxyhemoglobin (HbO2) and deoxyhemoglobin (Hb) can be evaluated selectively in extra- and intracerebral tissue compartments using the moments of distributions of times of flight of photons measured at two wavelengths in the near-infrared region. The combination of the data acquired from multiple sources and detectors located on the surface of the head with the depth-resolved analysis, based on the moments, enables imaging of cortex oxygenation. Results of the tests on physical phantoms as well as in vivo validation of the instrument during the motor stimulation experiment are presented.

Paper Details

Date Published: 1 May 2007
PDF: 14 pages
J. Biomed. Opt. 12(3) 034019 doi: 10.1117/1.2743964
Published in: Journal of Biomedical Optics Volume 12, Issue 3
Show Author Affiliations
Michal Kacprzak, Institute of Biocybernetics and Biomedical Engineering (Poland)
Adam Liebert, Institute of Biocybernetics and Biomedical Engineering (Poland)
Piotr Leszek Sawosz, Institute of Biocybernetics and Biomedical Engineering (Poland)
Norbert S. Zolek, Institute of Biocybernetics and Biomedical Engineering (Poland)
Roman Maniewski, Institute of Biocybernetics and Biomedical Engineering (Poland)


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