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Journal of Biomedical Optics

Three-dimensional diffuse optical tomography of osteoarthritis: initial results in the finger joints
Author(s): Zhen Yuan; Qizhi Zhang; Eric Sobel; Huabei Jiang
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Paper Abstract

This work presents a pilot study to show the potential of an emerging imaging modality, near-infrared diffuse optical tomography (DOT), for the diagnosis of osteoarthritis (OA). We report quantitative absorption and scattering images of joint tissue that allow for differentiation between diseased and healthy joints. An automatic, multichannel optical imaging system is used to image finger joints from two OA patients and three healthy volunteers. 3-D optical images of the joint tissue are recovered using a finite-element-based reconstruction algorithm. The reconstructed images demonstrate differences in optical properties at the joint region (cartilage/synovial fluid) between the OA and healthy joints. Quantitative analysis from the patients and healthy volunteers also indicate that the recovered joint sizes are consistent with those from x-ray findings. The results of this pilot study show potential for quantitative imaging and diagnosis of early OA by DOT.

Paper Details

Date Published: 1 May 2007
PDF: 11 pages
J. Biomed. Opt. 12(3) 034001 doi: 10.1117/1.2737420
Published in: Journal of Biomedical Optics Volume 12, Issue 3
Show Author Affiliations
Zhen Yuan, Univ. of Florida (United States)
Qizhi Zhang, Univ. of Florida (United States)
Eric Sobel, Univ. of Florida (United States)
Huabei Jiang, Univ. of Florida (United States)

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