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Journal of Biomedical Optics

Probing the low-frequency vibrational modes of viruses with Raman scattering—bacteriophage M13 in water
Author(s): Kong-Thon Tsen; Eric C. Dykeman; Otto F. Sankey; Shaw-Wei D. Tsen; Nien-Tsung Lin; Juliann G. Kiang
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Paper Abstract

Raman spectroscopy is used to study low-wave-number (≤20 cm-1) acoustic vibrations of the M13 phage. A well-defined Raman line is observed at around 8.5 cm-1. The experimental results are compared with theoretical calculations based on an elastic continuum model and appropriate Raman selection rules derived from a bond polarizability model. The observed Raman mode is shown to belong to one of the Raman-active axial modes of the M13 phage protein coat. It is expected that the detection and characterization of this low-frequency vibrational mode can be used for applications in biomedical nanotechnology such as for monitoring the process of virus functionalization and self-assembly.

Paper Details

Date Published: 1 March 2007
PDF: 6 pages
J. Biomed. Opt. 12(2) 024009 doi: 10.1117/1.2718935
Published in: Journal of Biomedical Optics Volume 12, Issue 2
Show Author Affiliations
Kong-Thon Tsen, Arizona State Univ. (United States)
Eric C. Dykeman, Arizona State Univ. (United States)
Otto F. Sankey, Arizona State Univ. (United States)
Shaw-Wei D. Tsen, Johns Hopkins Univ. (United States)
Nien-Tsung Lin, Tzu Chi Univ. (Taiwan)
Juliann G. Kiang, Walter Reed Army Institute of Research (United States)


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