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Journal of Biomedical Optics

Nonlinear optical interference of two successive coherent anti-Stokes Raman scattering signals for biological imaging applications
Author(s): Eunseong Lee; Jae Yong Lee; Yong Shim Yoo
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Paper Abstract

The nonlinear optical interference of two successively generated coherent anti-Stokes Raman scattering (CARS) signals from two different samples placed in series is demonstrated for the imaging performance, in which a collinear phase matching geometry is used. The relative phase of two CARS signals is controlled by a phase-shifting unit made of dispersive glass materials of which the thickness can be precisely varied. The clear interference fringes are observed as the thickness of the phase-shifting unit changes. The interference effect is then utilized to achieve a better quality CARS image of a biological tissue taken from a mouse skin. Placing the tissue in the second sample position and performing raster scans of the laser beams on it, we can acquire a CARS image of higher contrast compared to the normal image obtained without interferometric implementation.

Paper Details

Date Published: 1 March 2007
PDF: 5 pages
J. Biomed. Opt. 12(2) 024010 doi: 10.1117/1.2718560
Published in: Journal of Biomedical Optics Volume 12, Issue 2
Show Author Affiliations
Eunseong Lee, Korea Research Institute of Standards and Science (South Korea)
Jae Yong Lee, Korea Research Institute of Standards and Science (South Korea)
Yong Shim Yoo, Korea Research Institute of Standards and Science (South Korea)


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