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Journal of Biomedical Optics • Open Access

Intracellularly grown gold nanoparticles as potential surface-enhanced Raman scattering probes
Author(s): Ali Shamsaie; Magdalena Jonczyk; Jennifer D. Sturgis; J. Paul Robinson; Joseph Irudayaraj

Paper Abstract

Gold nanoparticles grown within the intracellular confines of living cells are introduced as potential surface-enhanced Raman scattering (SERS) substrates for confocal Raman spectrometry. Electron microscopy and a silver-enhanced reflectance laser scanning confocal microscopic approach were used to visualize the size, shape, and distribution of intracellularly grown gold nanoparticles (IGAuN) as small as 1 nm. Passive uptake as the conventional approach for delivering nanoparticles inside cells faces the insurmountable challenge of escaping the endosomal/lysosomal pathway. In contrast, IGAuN provides an unprecedented advantage of providing access to cytoplasm and nucleus.

Paper Details

Date Published: 1 March 2007
PDF: 3 pages
J. Biomed. Opt. 12(2) 020502 doi: 10.1117/1.2717549
Published in: Journal of Biomedical Optics Volume 12, Issue 2
Show Author Affiliations
Ali Shamsaie, Purdue Univ. (United States)
Magdalena Jonczyk, Purdue Univ. (United States)
Jennifer D. Sturgis, Purdue Univ. (United States)
J. Paul Robinson, Purdue Univ. (United States)
Joseph Irudayaraj, Purdue Univ. (United States)

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