Share Email Print

Journal of Biomedical Optics

Finding the position of tumor inhomogeneities in a gel-like model of a human breast using 3-D pulsed digital holography
Author(s): María del Socorro Hernández-Montes; Carlos Pérez López; Fernando Mendoza Santoyo
Format Member Price Non-Member Price
PDF $20.00 $25.00

Paper Abstract

3-D pulsed digital holography is a noninvasive optical method used to measure the depth position of breast tumor tissue immersed in a semisolid gel model. A master gel without inhomogeneities is set to resonate at an 810 Hz frequency; then, an identically prepared gel with an inhomogeneity is interrogated with the same resonant frequency in the original setup. Comparatively, and using only an out-of-plane sensitive setup, gel surface displacement can be measured, evidencing an internal inhomogeneity. However, the depth position cannot be measured accurately, since the out-of-plane component has the contribution of in-plane surface displacements. With the information gathered, three sensitivity vectors can be obtained to separate contributions from x, y, and z vibration displacement components, individual displacement maps for the three orthogonal axes can be built, and the inhomogeneity's depth position can be accurately measured. Then, the displacement normal to the gel surface is used to find the depth profile and its cross section. Results from the optical data obtained are compared and correlated to the inhomogeneity's physically measured position. Depth position is found with an error smaller than 1%. The inhomogeneity and its position within the gel can be accurately found, making the method a promising noninvasive alternative to study mammary tumors.

Paper Details

Date Published: 1 March 2007
PDF: 5 pages
J. Biomed. Opt. 12(2) 024027 doi: 10.1117/1.2717515
Published in: Journal of Biomedical Optics Volume 12, Issue 2
Show Author Affiliations
María del Socorro Hernández-Montes, Ctr. de Investigaciones en Óptica, A.C. (Mexico)
Carlos Pérez López, Ctr. de Investigaciones en Óptica, A.C. (Mexico)
Fernando Mendoza Santoyo, Ctr. de Investigaciones en Óptica, A.C. (Mexico)

© SPIE. Terms of Use
Back to Top