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Journal of Biomedical Optics • Open Access

Cortical blood flow assessment with frequency-domain laser Doppler microscopy
Author(s): Michael Atlan; Benoît Claude Forget; Claude Boccara; Tania Vitalis; Armelle Rancillac; Andrew K. Dunn; Michel Gross

Paper Abstract

We report the assessment of cerebral blood flow (CBF) changes with a wide-field laser Doppler imager based on a CCD camera detection scheme, in vivo, in mice. The setup enables the acquisition of data in minimally invasive conditions. In contrast with conventional laser Doppler velocimeters and imagers, the Doppler signature of moving scatterers is measured in the frequency domain, by detuning a heterodyne optical detection. The quadratic mean of the measured frequency shift is used as an indicator of CBF. We observe a significant variability of this indicator in an experiment designed to induce blood flow changes.

Paper Details

Date Published: 1 March 2007
PDF: 8 pages
J. Biomed. Opt. 12(2) 024019 doi: 10.1117/1.2715184
Published in: Journal of Biomedical Optics Volume 12, Issue 2
Show Author Affiliations
Michael Atlan, École Supérieure de Physique et de Chimie Industrielles (France)
Benoît Claude Forget, Univ. Pierre et Marie Curie (France)
Claude Boccara, Ctr. National de la Recherche Scientifique (France)
Tania Vitalis, École Supérieure de Physique et de Chimie Industrielles (France)
Armelle Rancillac, École Supérieure de Physique et de Chimie Industrielles (France)
Andrew K. Dunn, The Univ. of Texas/Austin (United States)
Michel Gross, Lab. Kastler Brossel (France)

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