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Journal of Biomedical Optics • Open Access

Real-time microscopic visualization of tissue response to laser thermal therapy
Author(s): Benjamin J. Vakoc; Guillermo J. Tearney; Brett E. Bouma

Paper Abstract

We present methods for visualizing the dynamic response of biological samples to laser-induced heating. Our approach utilizes optical frequency-domain imaging to detect, spatially localize, and monitor unique dynamic signatures that arise within zones of active tissue denaturation. Since this information is precisely registered with high-resolution (~10 µm) cross sectional images, regions of thermally destroyed tissue can be mapped in relation to pre-existing morphology. Using porcine esophageal specimens ex vivo, we demonstrate that the extent and evolution of laser thermal damage can be assessed in real time.

Paper Details

Date Published: 1 March 2007
PDF: 3 pages
J. Biomed. Opt. 12(2) 020501 doi: 10.1117/1.2714027
Published in: Journal of Biomedical Optics Volume 12, Issue 2
Show Author Affiliations
Benjamin J. Vakoc, Massachusetts General Hospital (United States)
Guillermo J. Tearney, Massachusetts General Hospital (United States)
Brett E. Bouma, Massachusetts General Hospital (United States)

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