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Journal of Biomedical Optics

Near-infrared spectroscopy measurement of the pulsatile component of cerebral blood flow and volume from arterial oscillations
Author(s): George Themelis; Helen E. D'Arceuil; Solomon G. Diamond; Sonal Thaker; Theodore J. Huppert; David A. Boas; Maria Angela Franceschini
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Paper Abstract

We describe a near-infrared spectroscopy (NIRS) method to noninvasively measure relative changes in the pulsate components of cerebral blood flow (pCBF) and volume (pCBV) from the shape of heartbeat oscillations. We present a model that is used and data to show the feasibility of the method. We use a continuous-wave NIRS system to measure the arterial oscillations originating in the brains of piglets. Changes in the animals' CBF are induced by adding CO2 to the breathing gas. To study the influence of scalp on our measurements, comparative, invasive measurements are performed on one side of the head simultaneously with noninvasive measurements on the other side. We also did comparative measurements of CBF using a laser Doppler system to validate the results of our method. The results indicate that for sufficient source-detector separation, the signal contribution of the scalp is minimal and the measurements are representative of the cerebral hemodynamics. Moreover, good correlation between the results of the laser Doppler system and the NIRS system indicate that the presented method is capable of measuring relative changes in CBF. Preliminary results show the potential of this NIRS method to measure pCBF and pCBV relative changes in neonatal pigs.

Paper Details

Date Published: 1 January 2007
PDF: 7 pages
J. Biomed. Opt. 12(1) 014033 doi: 10.1117/1.2710250
Published in: Journal of Biomedical Optics Volume 12, Issue 1
Show Author Affiliations
George Themelis, Massachusetts General Hospital (United States)
Helen E. D'Arceuil, Massachusetts General Hospital (United States)
Solomon G. Diamond, Massachusetts General Hospital (United States)
Sonal Thaker, Harvard Univ. (United States)
Theodore J. Huppert, Massachusetts General Hospital (United States)
David A. Boas, Massachusetts General Hospital (United States)
Maria Angela Franceschini, Massachusetts General Hospital (United States)

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